View abstract View article PDF The potential impacts of climate change on crop productivity are of widespread interest to those concerned with addressing climate change and improving global food security. Two common approaches to assess these impacts are process-based simulation models, which attempt to represent key dynamic processes affecting crop yields, and statistical models, which estimate functional relationships between historical observations of weather and yields. Examples of both approaches are increasingly found in the scientific literature, although often published in different disciplinary journals. Here we compare published sensitivities to changes in temperature, precipitation, carbon dioxide CO 2and ozone from each approach for the subset of crops, locations, and climate scenarios for which both have been applied.
This scientific journal includes a wide range of fields in its discipline to create a platform for the authors to make their contribution towards the journal and the editorial office at Omics International promises a peer review process for the submitted manuscripts to maintain the quality of free journals.
The jounal is among the best open access journals and aims to publish most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. Article published in drug designing journal are freely available online without any restrictions or any other subscriptions to the researchers worldwide.
The journal is using Editorial Tracking System for quality in peer review process. Drug designing journals have been showing tremendous citations and articles focusing the most advanced research trends in the field of drug discovery, medicinal chemistry, Drug Design tools, protein engineering, bioinformatics.
Editorial Manager is an online manuscript submission, review and tracking systems. Review processing is performed by the editorial board members of Drug Designing: Authors may submit manuscripts and track their progress through the system, hopefully to publication.
Reviewers can download manuscripts and submit their opinions to the editor. Drug Designing Drug design is an splendid inventive process of new medication on the basis of biological target. It is also known as rational drug design or rational design.
That is the invention in medical history in order to yield significant therapeutic response. The drug is an organic molecule, when it is bind to target site it can either inhibit or activate the function of a biomolecule which results in therapeutic benefit.
The drug design involves the design of such molecules that are similar to the bio molecular target site in shape and charge in order to bind to it.
Drug design relies on the knowledge of the three dimensional structure of bimolecular targets. Fragment Based Drug Design Fragment based drug design is identification of fragments or components of low molecular weight or lead compounds, which can bind with weak affinity to the target site.
Fragment based discovery involved finding such weakly binding fragments and grow them or combine them in order to create lead components with higher affinity or selectivity to bimolecular target site. These techniques achieved credible success in drug development.
Structure Based Drug Design Structure based drug design is the process of designing a chemical structure with the objective of identifying a compound which suits for clinical tests. The process involves how that shapes and charges to interact with biological target inorder to yield therapeutic activity.
Structure based drug design based on three dimensional structures strictly. In Silico Methods In silico methods with use of bioinformatics are in increasing demand in drug discovery and development that can identify and analyze active sites and suggest potential drug molecules that can bind to these sites specifically.
They analyze the target structures for possible binding sites, generate candidate molecules, check for their drug likeness, dock these molecules with the target, rank them according to their binding affinitiesfurther optimize the molecules to improve binding characteristics.
Molecular Modeling Molecular modeling is a tool which helps in the generation, manipulation or representation of three dimensional structures of molecule and associated physico chemical properties as well.
Molecular modeling helps to investigate, interpret and discovery of new phenomena. Heat Shock Proteins Heat shock proteins are the proteins that produced when cells are expose to the biologically stressful conditions.
Some selected heat shock proteins also known as chaperones. Increased temperature and some internal changes such as PH change will lead to the proteins to denature which cannot morphologically, functionally normal and leads to unfold of proteins that miss folded proteins aggregates and eventually kills the cell.
Heat Shock Proteins are induced rapidly at high levels to deal with this problem. These can able to mediate the synthesisstability and transulation ability of mRNA.
Each antibody can bound with specific antigen which is due to specific chemical constitution of the particular antibody. This is the reaction which keeps the body free from and protected from pathogens, chemical toxins and foreign bodies. Immunity of the humans is mediated by this specific phenomena.
Nanomedicals Nanomedicine is the application of the nanotechnologywhich ranges from application of nanomaterials to nanoelectronic biosensors medicinally.
The functionality can be attain to nanomedicine by interact with them biomolecule. As most of nanomaterial structure is similar to the biological structures these can be widely useful for in vitro and in vivo researches.
With of invention its widely using in the development of diagnostic devices, analytical tools, drug delivery vehicles and physical therapy applications.
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|Publication database||The Promise of Epigenetics in Early Stage Drug Discovery Epigenetic targets are exciting to drug discovery scientists because they hold great potential across a wide spectrum of therapeutic areas. The field of epigenetics focuses on the investigation of enzymes that alter gene expression through modification of their target substrates, usually through the addition or removal of methyl or acetyl groups.|
Agonists activates receptors to produce desired action whereas the antagonists blocks the action of agonist upon the binding to receptor. Peptidomimetic Peptidomimetics are the compounds whose pharmacophores that is their essential elements mimic a natural peptide or protein in order to retain the ability to interact with the specified biological target and produce same biological effect.
With the changed structure can attain significant molecular properties like desired biological activity and stability. These are responsible for many life and death processes. Whereas protease inhibitors are blocks the activity of protease enzymes which helps in the growth life threatening viruses and immature them and make them unable to infect new cells.Dynamic and efficient, the Oncodistinct Network aims to respond to the exponential changes in the oncology research landscape by accelerating treatment individualization, promoting multidisciplinarity and challenging current practices, particularly in settings with unmet medical need.
George TS has done his Master’s in Advanced Manufacturing Engineering from NITK Surathkal and has last worked as a Research Associate working on the development of an Intracranial stent at the Sree Chitra Institute for Medical Sciences and Technology, Thiruvananthapuram.
We offer postgraduate research PhD, MPhil, MSc by computer aided drug designing research papers Research and automotive technician research papers EngD programmes International Journal of Engineering Research and Applications (IJERA) is an open access action research paper format online peer Professional research paper .
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Journal of Drug Design and Research is an interdisciplinary, open access, peer reviewed journal that brings about latest research in all related fields of Drug Design and Research focusing upon the successes in drug designing methodologies and new drugs that have been developed and the insights and advances from the combined use of chemical .